Wegovy and Ozempic (semaglutide) are medications that can help regulate blood sugar, especially if you have high blood sugar or diabetes. These drugs may also promote weight loss and improve heart health.
Wegovy and Ozempic have the same active ingredient, semaglutide, a medication used for type 2 diabetes and chronic weight management.
While these medications contain the same active ingredient among several other similarities, they have key differences, including their approved uses and the functions they support in the body.
This blog will explain the differences between Wegovy and Ozempic to help you better understand both drugs.
What Is the Difference Between Ozempic and Wegovy?
Wegovy and Ozempic have similarities in several ways. One is the active ingredient, semaglutide, which belongs to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists.
While Wegovy and Ozempic share similarities, both medications are FDA-approved for different uses.
Ozempic is FDA-approved to:
- Help regulate blood sugar levels in people with type 2 diabetes.
- Lower the risk of major cardiovascular health issues like stroke, heart attack, or death in people with type 2 diabetes and heart disease.
While Ozempic is not FDA-approved for weight loss, a medical professional may prescribe it off-label to help with weight management. Off-label is when a doctor prescribes a medication for a use other than what the FDA approves it for.
Wegovy, on the other hand, is FDA-approved to treat obesity (body mass index (BMI) of 30 kg/m2 or higher) in adults and children over 12 years old. It is also approved for people who are overweight (BMI of 27 kg/m2 or higher) and have at least one weight-related medical condition, like high blood pressure, type 2 diabetes, or high cholesterol.
In March 2024, Wegovy was also FDA-approved to help lower the risk of death, stroke, or heart attack in people with a history of cardiovascular disease.
Another key difference between the two medications is how Wegovy and Ozempic pens are used. Every injection pen made with Wegovy features a built-in needle. The pen is used once and disposed of in a sharps container afterward. In contrast, Ozempic comes with needles you must attach to the injector pen before administering each dose. Afterward, you should put the needle in a sharps container and use the same pen.
How Does Semaglutide (Ozempic and Wegovy) Work?
These medications work similarly to GLP-1, a hormone naturally produced by the gut after meals. This hormone tells your body to produce more insulin to help lower blood sugar levels naturally.
High GLP-1 levels send a brain signal that tells your body you are full, which can help you feel less hungry. Semaglutide also slows down food digestion, helping you feel fuller more quickly.
How Does Ozempic Work?
As a GLP-1, Ozempic functions similarly to the hormone GLP-1 produced by the body. It attaches itself to GLP-1 receptors and signals the pancreas to release insulin into the bloodstream in response to increased blood sugar. The body produces more insulin, which lowers blood sugar levels. Because Ozempic mimics the GLP-1 hormone, it successfully stabilizes blood glucose levels in people with type 2 diabetes.
Ozempic also contributes to blood sugar stability by delaying the rate of digestion and prolonging the time food stays in the stomach. This reduces the amount of sugar released into the bloodstream and lowers the amount of food consumed by reducing appetite. Lastly, GLP-1 receptor agonists, like Ozempic, signal the brain when you’re full after eating, adding another layer of appetite regulation. This, in turn, promotes weight loss.
How Does Wegovy Work?
Since Ozempic and Wegovy share the same active ingredient, semaglutide, Wegovy works the same way as Ozempic. By increasing the body’s production of GLP-1, Wegovy holds food in the stomach longer, signaling the brain when you’re full. All of it controls your hunger and contributes to substantial weight loss.
Wegovy vs. Ozempic: Which One Is Effective?
Wegovy and Ozempic effectively control blood sugar and reduce body weight. But their effectiveness can differ.
Several studies have shown that Ozempic effectively lowers hemoglobin A1C (HbA1C) and weight in people with diabetes. A study on people with type 2 diabetes showed that taking 1 mg of Ozempic once a week resulted in weight loss of about 10 pounds over 30 weeks.
Wegovy may have higher weight-loss impacts. In one trial, the drug manufacturer found that taking 2.4 mg of Wegovy once a week for more than a year led to about 15% weight loss in 50.5% of people with obesity and no history of diabetes. Over 68 weeks, this weight loss was equal to about 33.7 pounds. The study also noted improved blood pressure, cholesterol, and metabolic health.
Many studies suggest that Wegovy may be a useful Ozempic alternative for patients with type 2 diabetes who wish to use it off-label. It demonstrates the potential for long-term care and disease prevention.
Studies conducted over an extended period have shown a beneficial link between a 2.4 mg dosage of semaglutide combined with lifestyle changes and a decreased risk of type 2 diabetes. People who take 2.4 mg of Wegovy may lower their risk of type 2 diabetes by up to 60%.
Wegovy vs. Ozempic: Dose and Administration
Wegovy and Ozempic come as injection pens that are already loaded with the drug. Both medications are started at a lower dosage and increased gradually based on your results, side effects, and treatment goals.
Ozempic comes in four different pre-filled multi-dose syringe pen dosages. These are: 0.25 mg, 0.5 mg, 1.0 mg, and 2.0 mg. Each pen has four dosages or a 30-day supply. Your precise dosage will determine how many pens you receive. The maximum dosage of Ozempic is 2 mg.
Wegovy, on the other hand, is available in five different single-dose, pre-filled syringes. Its strengths are 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg. For a 30-day supply, you will need four pens since each includes one dose. The maximum dosage for Wegovy is 2.4 mg once each week.
Is Wegovy Good for People With Diabetes?
You might qualify for Wegovy if you have type 2 diabetes. Your healthcare provider may prescribe it as part of your weight-management strategy.
A clinical trial studied Wegovy’s effect on people with type 2 diabetes. After 68 weeks, participants in the treatment dropped, on average, almost 10% of their initial body weight. They also noticed an improvement in their A1C levels.
Wegovy is not approved for type 2 diabetes. However, because of how it works, taking it may have some positive effects on blood sugar. Losing weight healthily may also improve blood sugar levels.
Cost of Ozempic vs. Wegovy
The cost of Ozempic and Wegovy can vary depending on your dosage, insurance coverage, and pharmacy. Without insurance, the out-of-pocket cost for Ozempic is about $900 monthly, while Wegovy can cost $1,400 monthly.
If you have insurance, these costs may be significantly reduced, especially if your plan covers one or both medications. Additionally, manufacturer savings programs and discount cards may help lower expenses further. It’s important to check with your insurance provider and pharmacy to understand the exact costs and explore any available discounts.
At NP2GO, we offer compounded semaglutide at a significantly lower cost, making it an affordable alternative. We also provide virtual visits for just $99, reducing the need for costly in-office appointments and offering personalized weight loss support at a fraction of the price.
Does Insurance Cover Wegovy and Ozempic?
Insurance coverage for Wegovy and Ozempic can vary significantly depending on your plan. Ozempic may be more likely to be covered, particularly for treating type 2 diabetes.
On the other hand, Wegovy, which is primarily prescribed for weight management, may not be covered by several insurance plans. It’s essential to contact your insurance provider directly to get precise details on what is covered under your plan.
If you have commercial insurance, you may reduce the cost of these medications by using a manufacturer’s savings card, which can significantly lower out-of-pocket expenses.
Some insurance companies, such as Blue Cross Blue Shield and Tricare, may cover Wegovy, Ozempic, and other weight loss medications, but coverage often comes with specific criteria that must be met. This can include a documented history of weight-related health issues or prior attempts at weight loss through other means.
While we do not accept insurance at NP2GO, we are committed to helping you navigate the process by helping you complete prior authorization forms, which can increase the likelihood of your insurance covering the medication.
Risks and Side Effects of Ozempic vs. Wegovy
Since Ozempic and Wegovy are GLP-1 receptor agonists, contain the same active ingredient, semaglutide, and share similar mechanisms of action, the two drugs’ side effects are very similar.
Common Side Effects
The most common side effects for Ozempic and Wegovy include gastrointestinal issues such as nausea, vomiting, diarrhea, constipation, abdominal pain, and injection site reactions.
These symptoms are typically more pronounced when you first start the medication or when the dosage is increased. While these side effects often go away with time, they can persist for some people.
Serious Side Effects
Both medications risk more severe side effects, though these are less common. They may include:
- Pancreatitis: Inflammation of the pancreas, which can cause severe abdominal pain, nausea, and vomiting.
- Gallbladder issues: Both medications may increase the risk of gallbladder problems, including gallstones.
- Thyroid tumors: Animal studies have shown an increased risk of thyroid C-cell tumors with GLP-1 receptor agonists, including Ozempic and Wegovy. Although this has not been confirmed in humans, it’s a potential risk to be aware of.
- Hypoglycemia: Particularly when used in combination with other diabetes medications, there is a risk of low blood sugar (hypoglycemia) with Ozempic.
While Ozempic and Wegovy have many similar side effects, the intensity and likelihood of these effects can differ. Wegovy, for instance, may have more intense nausea and gastrointestinal issues, mainly because it is administered at a higher dosage than Ozempic.
Who Should Avoid These Medications?
Both Ozempic and Wegovy are not recommended for people with a personal or family history of medullary thyroid carcinoma (MTC) or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Additionally, those with a history of pancreatitis or severe gastrointestinal issues should discuss the risks with their healthcare provider before starting either medication.
Ozempic and Wegovy are not recommended for pregnant women, those trying to conceive, or breastfeeding mothers due to potential risks to the baby. It’s advised to stop these medications at least two months before trying to conceive and to avoid them while breastfeeding. Always consult your healthcare provider for safer alternatives during these stages.
Can You Switch From Ozempic to Wegovy?
Switching between Ozempic and Wegovy and vice versa may be safe, but only under the guidance of your healthcare provider. While both medications are GLP-1 receptor agonists and share the same active ingredient, they are prescribed for different primary functions.
Before switching, your healthcare provider will consider factors such as your current health status, treatment goals, and potential side effects. They will also help adjust the dosage and monitor your response to ensure a smooth transition and minimize any risks or side effects associated with the switch.
Do not use Ozempic and Wegovy simultaneously, as both are GLP-1 receptor agonists. These medications should not be combined with other GLP-1 receptor agonists or weight loss products, including prescription medications, over-the-counter drugs, or herbal remedies.
Wegovy vs. Ozempic: Key Differences and Similarities
Here’s a table summarizing the key differences and similarities between Wegovy and Ozempic:
| Aspect | Wegovy | Ozempic |
|---|---|---|
| Primary Use | Obesity management and weight loss | Type 2 diabetes management and cardiovascular risk reduction |
| FDA Approval | Weight management (BMI ≥ 30 or BMI ≥ 27 with weight-related conditions); cardiovascular risk reduction (as of March 2024) | Type 2 diabetes management; cardiovascular risk reduction in people with type 2 diabetes and heart disease |
| Active Ingredient | Semaglutide | Semaglutide |
| Monthly Cost | About $900 | About $1400 |
| Starting Dose | 0.25 mg weekly | 0.25 mg weekly |
| Maximum Dose | 2.4 mg weekly | 2 mg weekly |
| Effectiveness for Weight Loss | Up to 15% weight loss | Weight loss of about 10 pounds in 30 weeks |
| Effectiveness for Blood Sugar Control | Not FDA-approved; may help with blood sugar control off-label | Effective for blood sugar control in type 2 diabetes |
| Insurance Coverage | May vary; often, less coverage for weight management | More likely to be covered, particularly for type 2 diabetes |
| Common side effects | Nausea, vomiting, diarrhea, constipation, and abdominal pain | Nausea, vomiting, diarrhea, constipation, and abdominal pain |
| Serious side effects (rare) | Pancreatitis, gallbladder issues, thyroid tumors | Pancreatitis, gallbladder issues, thyroid tumors, and the risk of hypoglycemia |
Ozempic vs. Wegovy: Which One Should You Choose?
Choosing Ozempic or Wegovy depends on your specific health needs and treatment goals. The ideal prescription medication for you might not be the best for someone else.
When deciding between these medications, consider your primary health goals.
If managing type 2 diabetes and reducing cardiovascular risk are your main concerns, Ozempic may be a better option. However, if your primary goal is significant weight loss and reducing cardiovascular risk, Wegovy could be more suitable.
Both medications share a similar mechanism of action and potential side effects, but their specific approvals and uses can guide your choice.
Talk with your healthcare provider about both options. They can check your medical history, treatment objectives, and any potential side effects and help you determine which medication best meets your personal needs and health goals.
Get Wegovy or Ozempic in the US.
Ozempic and Wegovy are powerful tools for managing weight and improving overall health, particularly for those struggling with obesity or type 2 diabetes. These medications, known for their effectiveness in regulating blood sugar and supporting weight loss, can significantly impact your journey toward better health.
At NP2GO, we provide personalized services tailored to your needs. Our team includes registered obesity nurses who specialize in creating weight loss plans that work for you. Whether you prefer the convenience of telehealth or the support of in-office visits, we’re here to guide you every step of the way.
We proudly serve clients in over 28 states, including Washington, Oklahoma, Florida, and Texas. If you’re ready to take the next step in your weight-loss journey, contact us today to learn how we can support your goals.