Since the FDA approved the once-weekly injectable weight loss medication, Zepbound (tirzepatide), in 2023, it has garnered significant media attention. This is because it can help those who are overweight or obese lose substantial weight.
If you’ve just started on this medication, your Zepbound healthcare provider probably went over the drug’s fundamentals with you. Since then, you may have had questions like, “How long does it take for Zepbound to start working?” And, “How much weight can I lose on Zepbound?” This post will answer those and other frequently asked questions about Zepbound.
How Does Zepbound Work for Weight Loss?
Zepbound differs from other weight-loss injections, such as Wegovy or Saxenda. It’s the first drug of its kind that targets GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide) receptors.
GIP and GLP-1 are gut hormones produced by your body naturally after meals. These hormones signal your pancreas to increase insulin production after a meal. They also help regulate the synthesis of fresh glucose. GIP and GLP-1 also control hunger and the passage of food through the intestines.
They communicate these messages by binding to their unique receptors, the GIP and GLP-1 receptors. Zepbound works by promoting the production of natural GLP-1 and GIP hormones in your body. However, the drug’s effects stay longer than those of your body’s natural hormones.
Therefore, Zepbound helps you feel fuller longer, decreases your appetite and cravings, and increases insulin production. When combined, these actions result in decreased blood glucose levels and weight loss. That’s why tirzepatide is approved as two standalone medications: Mounjaro for type 2 diabetes and Zepbound for chronic weight management.
How Long Does It Take for Zepbound (Tirzepatide) to Work?
If you use Zepbound, it may take a few weeks before you notice any changes in your appetite or weight. Your doctor will need to increase your Zepbound dosage gradually until it reaches the highest effective level. For the first four weeks of your treatment, you will be started on a low dose (2.5 mg). This dose is designed to help your body adjust to the medicine.
Your dose will be increased to 5 mg once weekly after 4 weeks. Zepbound maintenance dosages are 5 mg, 10 mg, or 15 mg. Most people start to see changes in appetite and weight within 4 to 12 weeks of starting Zepbound, although results may vary from person to person.
The time it takes for tirzepatide to work for weight loss varies depending on several factors, including calorie intake, age, physical activity level, and any other medications you may be taking. As a result, there is no typical expected rate of weight loss.
In one Zepbound clinical trial, patients receiving high doses lost an average of nearly 20% of their body weight throughout the trial (approximately 16.5 months) after 12 weeks of an intensive diet and exercise regimen. The trial examined patients with a BMI of 30 or higher, or those with a BMI of 27 or higher and one additional medical condition, such as diabetes.
How Much Weight Can You Lose with Zepbound?
The amount of weight you can lose with Zepbound (tirzepatide) varies from person to person, depending on several factors, including dosage, individual response to the medication, and lifestyle choices like diet and exercise.
In a clinical trial of people with obesity or overweight and a weight-related health issue, Zepbound produced an average weight loss of 15-20% in a year and a half when used alongside diet and physical activity. This equates to an average of 34 to 48 lbs.
According to another study, the exact amount of weight loss depends on the dosage, with higher doses producing greater results. This study found that adults with obesity who took the highest doses of Zepbound (10–15 mg) lost an average of 15% of their body weight.
Furthermore, prolonged use of Zepbound may result in even greater weight loss. Patients participating in two different clinical trials saw consistent weight loss over time, with an average loss of 25% of their initial body weight. Each study lasted for 72 weeks.
Why Am I Not Losing Weight on Zepbound?
While Zepbound (tirzepatide) has been shown to be effective for weight loss in many people, some may experience slower progress or hit a plateau. Here’s why you’re not losing weight on Zepbound:
1. Your dosage is too low
Zepbound treatment begins with a lower dose of 2.5 mg, which is gradually increased by 2.5 mg every 4 weeks. If you’re on a lower dose, it may take longer to see desired results. Speak with your healthcare provider about adjusting your dose to ensure it aligns with your weight loss goals.
2. You’ve not changed your diet
Weight loss with Zepbound is most effective when combined with a healthy, low-calorie diet. Although the medication helps suppress appetite, consuming high-calorie or highly processed foods can hinder your weight loss progress. It’s essential to consume a low-calorie diet and foods low in fat to optimize the benefits of Zepbound.
3. You’re not physically active
While Zepbound can help reduce weight on its own, exercising regularly can enhance your results. A sedentary lifestyle may prevent you from achieving the full potential of the medication. Adding exercise into your daily routine—even light activities like walking around your neighborhood, skipping rope, or doing yoga—can help you achieve your goals.
4. You’ve reached a plateau
Some people may experience an initial weight loss followed by a plateau as their bodies adjust to the medication. This is normal and doesn’t mean Zepbound has stopped working. To overcome this, focus on maintaining consistency with your treatment plan and making gradual changes to your routine, such as modifying your diet or increasing physical activity.
5. You have a medical condition or are on other medications
Some pre-existing medical conditions, like hypothyroidism or hormonal imbalances, can interfere with weight loss. Some medications, like antidepressants or corticosteroids, may also cause weight gain or make losing weight more challenging. If you suspect an underlying condition or medication is affecting your progress, discuss this with your healthcare provider.
6. You’re not consistent
Zepbound is most effective when used consistently and as prescribed. Skipping doses or not following your healthcare provider’s instructions may reduce the efficacy of the medication. Stick to the prescribed schedule and attend follow-up appointments to monitor your progress.
How long does a person have to take Zepbound?
Zepbound is prescribed as part of a long-term weight management plan. It is designed for chronic weight management rather than short-term use. You may need to take it for months or even years to achieve and maintain your target weight.
Once you achieve your weight loss goals, you may continue to take Zepbound to help maintain your results and prevent weight regain. In an Eli Lily trial, people with obesity or overweight and without diabetes lost more weight if they used Zepbound for 88 weeks than those who discontinued after 36 weeks. However, they retained a 9.5% weight loss.
FAQs About How Long It Takes for Zepbound (Tirzepatide) to Work
How fast does Zepbound work after injection?
Zepbound starts working shortly after your first injection by regulating appetite and blood sugar levels. However, noticeable weight loss typically occurs within the first 4 to 8 weeks as your body adjusts to the medication and the dosage increases. Consistent use, a healthy diet, and regular exercise enhance results over time.
During your first week on Zepbound, you may notice a reduced appetite and slower digestion, which can help you feel full for longer. Some people experience mild nausea, fatigue, or stomach discomfort as their body adjusts to the new medication. Staying hydrated, eating smaller meals, and avoiding rich or greasy foods can help ease early side effects.
What foods should I avoid while using Zepbound?
Avoid high-fat, fried, or sugary foods, as they can worsen nausea or gastrointestinal side effects. Also, limit alcohol and carbonated drinks, which may upset your stomach. Focus instead on lean proteins, vegetables, fruits, and whole grains to support steady weight loss and help Zepbound work more effectively.
Is it better to take Zepbound in the morning or at night?
You can take Zepbound at any time of day, but it’s best to inject it on the same day and at the same time each week for consistency. Many people prefer mornings to monitor for side effects, such as nausea. Choose the time that best fits your schedule and routine.
What are the best foods to eat while on Zepbound?
The best foods to eat while on Zepbound are high in protein and fiber, which help you feel full for longer and maintain muscle mass. Include lean proteins such as chicken, fish, eggs, and tofu, along with plenty of vegetables, fruits, and whole grains. Choose small, balanced meals and stay well-hydrated throughout the day.
Achieve Your Weight Loss Goals with NP2GO’s Expert Care
At NP2GO, we understand that losing weight can be a challenging journey, but with the right support, it’s achievable. Our experienced team of healthcare providers offers personalized weight loss solutions, including telehealth consultations for Zepbound (tirzepatide) and other weight loss medications like Wegovy (semaglutide).
Serving clients nationwide, we offer the convenience of virtual visits and expert guidance to help you achieve your weight goals—whether you’re just starting out or require ongoing support.
Book an appointment with NP2GO today, and let us tailor a plan that fits your unique needs and lifestyle. With our affordable pricing, you’ll receive the care and attention you need to make lasting, positive changes.