Losing weight and keeping it off can be challenging. For women, it can be harder, even with diet and exercise. This may be because of factors like genetics, changes in activity level, hormonal fluctuations, eating habits, and how your body stores fat. And that’s where appetite suppressants come in.
Appetite suppressants are supplements or medications that reduce cravings and promote fullness. While they can be effective, they are not a quick weight-loss fix. They should be used alongside a balanced diet and regular exercise.
Explore the best appetite suppressants for women, from prescription medications to over-the-counter and natural appetite suppressants. Learn what they are and how they work.
What Are Appetite Suppressants?
Appetite suppressants are medicines or supplements that reduce hunger and curb cravings. Also known as diet pills, appetite suppressants influence the body’s hunger-regulating hormones, neurotransmitters, or digestive process to promote a feeling of fullness and prevent overeating.
The appetite suppressants available include prescription, over-the-counter (OTC), and natural appetite suppressants. Natural options, such as fiber-rich foods, green tea extract, and protein, help promote satiety, reducing the need to snack throughout the day. Prescription appetite suppressants are medications approved by the FDA for people with obesity or overweight who have certain medical conditions. They work by altering hunger-related hormones to reduce appetite.
Some supplements are also sold as appetite suppressants, but they’re not reviewed or approved by the FDA.
While appetite suppressants can be effective, they work best when combined with a healthy diet, regular exercise, and lifestyle changes.
Long-Term Best Prescription Appetite Suppressants for Women
The FDA has approved several long-term prescription appetite suppressants for chronic weight management. These appetite suppressants should be used alongside a balanced diet and increased exercise, and you can only get them with a healthcare professional’s prescription. They include:
Wegovy (semaglutide)
Wegovy (semaglutide) is an FDA-approved prescription medication designed for long-term weight management. It works by mimicking GLP-1 (glucagon-like peptide-1), an intestinal hormone that promotes insulin production, reducing hunger and increasing feelings of fullness.
The active ingredient in Wegovy is semaglutide. This appetite suppressant is beneficial for women struggling with chronic weight management issues, including those with conditions like PCOS, insulin resistance, or metabolic syndrome.
In a large clinical trial, people receiving the highest dose (2.4 milligrams) of Wegovy lost an average of 15% of their body weight over 68 weeks when combined with lifestyle changes.
Wegovy is injected once weekly under the skin of your upper arm, thigh, or abdomen using a prefilled pen. It’s started at a lower dose of 0.25 milligrams and gradually increased over a few months to a maximum of 2.4 milligrams, or according to your doctor’s recommendation.
Ozempic (semaglutide)
Ozempic (semaglutide) is the same as Wegovy. Both medications are GLP-1 receptor agonists containing the GLP-1 agonist semaglutide. However, Ozempic is approved to manage type 2 diabetes, but it has shown positive effects in appetite suppression and weight loss.
Like Wegovy, Ozempic mimics GLP-1, a hormone that helps regulate blood sugar levels, slows digestion, and promotes feelings of fullness, leading to reduced calorie intake and weight loss.
While Ozempic is FDA-approved for diabetes management, healthcare providers prescribe it off-label for weight loss, especially for women who struggle with appetite control due to insulin resistance or metabolic disorders.
People with diabetes taking higher doses of Ozempic (2 mg) lost about 13 to 15 lbs after 40 weeks.
Zepbound (tirzepatide)
Zepbound (tirzepatide) is a newly FDA-approved appetite suppressant that works as a dual GLP-1 and GIP receptor agonist. This means it activates two key hormones, GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide), to suppress appetite, slow digestion, and promote a feeling of fullness.
Two clinical trials have shown that people taking Zepbound lost up to 20% of their body weight over 72 weeks, making it one of the most effective prescription appetite suppressants.
Like Wegovy, Zepbound is prescribed in combination with a balanced diet and regular exercise to support weight loss. It is injected once weekly, with doses gradually increasing over time to minimize side effects.
Saxenda (liraglutide)
Saxenda is an injectable appetite suppressant that contains liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. Originally developed to treat type 2 diabetes under the brand name Victoza, liraglutide was later approved for weight management in adults with obesity or overweight with weight-related health conditions.
Like Wegovy, Saxenda helps suppress appetite by mimicking the effects of GLP-1 to increase feelings of fullness and reduce calorie intake.
Unlike Wegovy and Zepbound, which are taken once weekly, Saxenda requires a daily injection. While this may be less convenient, it’s still effective in helping women struggling with weight management.
Clinical studies have shown that people using Saxenda lost an average of 5-10% of their body weight over 56 weeks when combined with lifestyle changes.
When starting with Saxenda, your healthcare provider will start you at a lower dosage and gradually increase it over several weeks to minimize side effects and help your body adjust.
Contrave (naltrexone-bupropion)
Unlike injectable medications like Wegovy or Saxenda, Contrave is an oral prescription appetite suppressant that combines two FDA-approved drugs: naltrexone, used to treat opioid and alcohol dependence, and bupropion. These ingredients work on the brain’s reward system to reduce food cravings and control hunger.
Contrave blocks the brain’s reward system, making it easier to resist unhealthy food cravings, and acts on the hypothalamus, the brain’s hunger center, helping you feel fuller for longer.
In clinical trials, people with obesity or overweight who took Contrave combined with diet and exercise lost an average of 5-10% of their body weight over 56 weeks.
Qysmia (phentermine-topiramate)
Qsymia (phentermine-topiramate) is a prescription appetite suppressant that combines two well-known medications: phentermine, a stimulant, and topiramate, an anticonvulsant. These two medications combine to suppress appetite, increase feelings of fullness, and reduce cravings.
Qsymia is taken orally, usually once daily in the morning, and the dosage is gradually increased over several weeks to minimize side effects and help the body adjust.
Qsymia is approved for children 12 years and older with a BMI in the 95th percentile.
People taking the maximum dose of Qsymia, along with lifestyle changes, lost an average of 10-15% of their body weight over 56 weeks.
Short-Term Prescription Appetite Suppressants for Women
Some FDA-approved prescription appetite suppressants are only intended for short-term usage, up to 12 weeks. They include:
Phentermine (Adipex-P, Atti-Plex P, and Pro-Fast)
Phentermine is the oldest and most commonly prescribed short-term appetite suppressant. It belongs to a class of medications called anorectics, which suppress appetite by stimulating the central nervous system. It works by increasing the release of neurotransmitters, such as norepinephrine, which signals the brain to reduce hunger.
As a stimulant, it is chemically similar to amphetamines and is prescribed for short-term use–up to 12 weeks—because of the risk of dependence and side effects. Phentermine is available under brand names such as Adipex-P, Atti-Plex P, and Pro-Fast.
When combined with a low-calorie diet and exercise, phentermine has been shown to help people lose between 5% and 10% of their body weight within the first 12 weeks of use.
Phendimetrazine (Prelu-2)
Phendimetrazine is another effective prescription appetite suppressant option. As a stimulant-based appetite suppressant, phendimetrazine works similarly to phentermine. It stimulates the central nervous system to suppress appetite.
Phendimetrazine is prescribed for short-term use, a few weeks to a few months, as part of a comprehensive weight loss plan that includes diet, exercise, and behavioral changes.
Phendimetrazine is taken orally, usually 2-3 times a day, and you should take it 30 minutes to 1 hour before meals to maximize its appetite-suppressing effects.
Benzphetamine
Benzphetamine is a prescription appetite suppressant classified as a sympathomimetic amine, which means it stimulates the central nervous system to suppress appetite. It works by stimulating the central nervous system (CNS) to increase metabolism and reduce hunger signals.
Like phentermine and phendimetrazine, benzphetamine is a Schedule III controlled substance, meaning it has a potential for dependence and is only recommended for use up to 12 weeks under medical supervision.
Benzphetamine is taken by mouth once daily in the morning or as directed by a healthcare provider and should not be taken within 6 hours of normal bedtime, as it can cause insomnia.
Diethylpropion
Like benzphetamine, diethylpropion is classified as a sympathomimetic amine marketed as an appetite suppressant and used for short-term weight loss. Diethylpropion’s mechanism of action is similar to phentermine. It works by stimulating the release of neurotransmitters like norepinephrine and dopamine, signaling your brain to feel full even when eating less.
Clinical studies and real-world use have shown that when combined with a low-calorie diet and regular exercise, people using diethylpropion can lose up to 5-10% of their body weight within 12 weeks.
You should take diethylpropion orally, 3 times daily, or as directed by your healthcare provider, and you should take it 1 hour before meals to maximize its appetite-suppressing effects.
Best Over-the-counter (OTC) Appetite Suppressants
Over-the-counter appetite suppressants are non-prescription supplements that help reduce hunger and support weight loss. Unlike prescription appetite suppressants, which require a doctor’s recommendation and are used for medical weight management, OTC appetite suppressants are available in pharmacies, health stores, and online without a prescription.
OTC appetite suppressants are available in various forms, including pills, capsules, powders, and teas, and contain a mixture of ingredients like fiber, caffeine, herbal extracts, or other compounds that promote satiety and boost energy.
Unlike prescription appetite suppressants, some OTC options aren’t considered medications by the U.S. Food and Drug Administration (FDA), so the agency does not review them before they’re released to the market.
Because of this, be cautious when buying over-the-counter weight loss medication or herbal supplements. Most of the statements businesses make about their products are also not approved by the FDA. Talk with your healthcare provider before using them.
The only over-the-counter appetite suppressant approved by the FDA is Orlistat (Alli). It’s half as powerful compared to prescription orlistat (Xenical). It prevents the body from absorbing some of the fat from your food.
Best Natural Appetite Suppressants for Women
Natural appetite suppressants are foods, herbs, supplements, or nutrients that help reduce hunger, curb cravings, and support weight loss. While more research is needed, many natural options may help regulate appetite and promote satiety without the use of medications:
Glucomannan
Glucomannan is a fiber derived from the konjac root, known for its ability to absorb water and expand in the stomach, creating a feeling of fullness and prolonging gastric emptying. This slows digestion and helps reduce calorie intake.
Fenugreek
Fenugreek is an herb belonging to the legume family of plants. The seeds contain a type of soluble fiber called galactomannan, which absorbs water and expands in the stomach, creating a feeling of fullness and a reduced appetite.
Its high fiber content also helps regulate blood sugar levels, which can reduce hunger and cravings.
Green tea
Green tea is a well-known natural appetite suppressant that may support weight loss by boosting metabolism, reducing hunger, and increasing fat burning. It contains catechins, particularly epigallocatechin gallate (EGCG), which help regulate hunger hormones and enhance thermogenesis (the body’s process of burning calories).
Green tea also contains caffeine, a natural stimulant that can temporarily reduce appetite and improve energy levels, making it easier to stay active and maintain a calorie deficit.
Garcinia cambogia
Garcinia cambogia is a tropical fruit extract native to India and other South Asian countries. It contains an active compound called hydroxycitric acid (HCA), which is believed to help reduce hunger by increasing serotonin levels, a neurotransmitter that influences mood and appetite.
Protein-rich foods
Including lean protein sources, such as fish, poultry, eggs, tofu, and beans, in each meal may help you consume fewer calories. Lean protein helps regulate appetite by decreasing ghrelin, the hormone that signals hunger, and promoting the production of hormones linked to satiety. A high-protein diet also increases the calories your body burns at rest, which may help you lose weight.
Fiber-rich foods
Fiber-rich foods, such as fruits, vegetables, oats, and legumes, slow down the absorption and digestion of carbohydrates, prolonging feelings of fullness and helping you manage your weight.
Are Appetite Suppressants Safe?
Appetite suppressants can be safe and effective when used under the guidance of a healthcare provider. However, like any medication, they come with potential side effects.
Common side effects for long-term prescription appetite suppressants or GLP-1 receptor antagonists include:
- Nausea
- Vomiting.
- Diarrhea
- Constipation.
- Headaches.
- Fatigue.
- Low blood sugar (hypoglycemia)
Side effects for short-term appetite suppressants or stimulant-based medications include:
- Increased heart rate
- Increased blood pressure
- Insomnia
- Dry mouth
- Restlessness
- Anxiety
- Irritability
- Constipation
- Diarrhea
Side effects for OTC and natural appetite suppressants include:
- Restlessness
- Insomnia
- Increased heart rate.
- Headaches
- Bloating
- Abdominal cramps
- Diarrhea
- Constipation
FAQs About Appetite Suppressants for Women
Do appetite suppressants work?
Yes, appetite suppressants work. Clinical trials suggest that people who take long-term prescription appetite suppressants lose between 3% and 12% of their body weight in a year. That’s more than what most people can achieve with only lifestyle adjustments. Studies show that losing 5–10% of your body weight and maintaining that weight loss is sufficient to improve your health.
Can I use appetite suppressants while breastfeeding?
No, you should not take appetite suppressants while breastfeeding unless your doctor instructs you to. Some appetite suppressants can pass into breast milk and cause side effects in your baby, such as decreased appetite.
What is the best appetite suppressant that works?
The best appetite suppressant depends on individual needs. Wegovy (semaglutide) and Zepbound (tirzepatide) are highly effective long-term prescription options, whereas Phentermine is more suitable for short-term use. Natural options, such as protein, fiber, and green tea, can also be beneficial. For optimal results, consult your healthcare provider to determine the best choice.
Are there any natural ways to suppress appetite?
Yes, natural appetite suppressants include protein-rich foods, fiber, green tea, glucomannan, and healthy fats. Drinking plenty of water, managing stress, and getting enough sleep can also help control hunger. While natural methods are generally safer, their effects may be milder than those of prescription options.
Find the Right Appetite Suppressant with NP2GO
Choosing the right appetite suppressant can greatly impact your weight loss journey. Whether you’re considering prescription medications like Wegovy or Phentermine or want to explore natural appetite control options, finding a solution that works for your body and lifestyle is important.
At NP2GO, our expert nurse practitioners offer personalized weight loss consultations, helping women select the most suitable appetite suppressant for their individual needs. We make it easy to get started with affordable telehealth visits and transparent pricing.
Contact us today to schedule your consultation and start your journey toward a healthier, happier you.