In case you didn’t know, there’s a new drug on the market that promises to reduce body weight in people with obesity and type 2 diabetes. Tirzepatide is the first drug of its kind. This medication targets the glucagon-like peptide 1 receptor and the glucose-dependent insulinotropic polypeptide receptor to stimulate weight loss.
Semaglutide, a weight loss medication you’re likely more familiar with, targets just one of these receptors. So, what are the main differences between tirzepatide and semaglutide, and how do they work to help people with obesity and type 2 diabetes achieve their target weight?
Discover the main difference between tirzepatide and semaglutide, the efficacy, and the mechanisms involved in each drug’s ability to reduce body weight.
What Is Tirzepatide?
Tirzepatide, marketed under the brand names Zepbound and Mounjaro, is prescribed to adults with type 2 diabetes and weight loss issues. As a GIP and GLP-1 receptor agonist, tirzepatide helps people lose weight by reducing hunger and slowing the passage of food from the stomach into the small intestine. This may cause you to feel fuller for a longer period.
Tirzepatide also lowers blood sugar levels by decreasing the amount of sugar the liver makes and increasing insulin production.
Zepbound is FDA-approved for adults who are obese or overweight and who have weight-related medical conditions like hypertension or cardiovascular disease. Zepbound should be combined with a balanced diet and regular exercise to help you lose weight and maintain it.
Mounjaro is prescribed for people with type 2 diabetes to help control their blood sugar levels. It should also be used in conjunction with a balanced diet and regular exercise. Tirzepatide is the active ingredient in both Mounjaro and Zepbound, developed by Eli Lilly and Company. Both are administered subcutaneously once a week and come in single-dose pens with the same strengths: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg per 0.5 mL.
How Does Tirzepatide Work?
As a glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide mimics the hormone GLP-1, which is known to regulate hunger, causing people to eat less. It also imitates the GIP hormone (glucose-dependent insulinotropic polypeptide). This hormone is well known for raising blood glucose levels, which may lead to feelings of fullness.
Tirzepatide is also known to slow gastric emptying, which prolongs the time that food remains in the stomach, resulting in a feeling of fullness and satisfaction. Tirzepatide may also increase energy, leading to more frequent movement throughout the day and increased calorie burn.
What Is Semaglutide?
Semaglutide is another diabetic and weight loss drug available. Like tirzepatide, semaglutide is administered once weekly along with changing habits like diet and exercise.
Semaglutide is the active ingredient in Ozempic, Wegovy, and Rybelsus. It is a GLP-1 agonist that decreases glucagon release, increases insulin release, slows gastric emptying, and suppresses appetite. Wegovy injection is approved to help adults and children 12 years of age and older who are obese or some adults who are overweight and have weight-related medical issues lose and maintain their weight.
Ozempic is an injection prescribed to people with diabetes who have cardiovascular disease to help reduce the risk of cardiovascular events like a heart attack or stroke. Rybelsus is a tablet used to help control blood sugar levels in people with type 2 diabetes. It is taken once a day.
How Does Semaglutide Work?
While tirzepatide targets both the GLP-1 and the GIP receptor agonist, semaglutide only mimics the GLP-1 receptor agonist, which is released by your gut after you eat to signal the brain that you are full. Semaglutide promotes blood sugar control by raising the amount of insulin produced, decreasing the amount of glucagon released, and prolonging stomach emptying. It also regulates appetite, reducing your cravings.
Tirzepatide vs. Semaglutide: Which Is More Effective?
According to research, tirzepatide has shown a more significant reduction in body weight than semaglutide. However, additional comparative studies are needed to draw firm findings. It’s also important to remember that each person reacts differently to medications. Semaglutide may work better for some people than tirzepatide.
During a 72-week study, those receiving the maximum dose of tirzepatide lost an average of 21% of their body weight. This was compared to the placebo group, which saw a 3% loss. Studies on the efficacy of semaglutide have also been positive. Participants who were overweight or obese and took the medication lost an average of 5.9% of their body weight after three months (13 weeks) and 10.9% after six months (26 weeks).
Tirzepatide’s more significant weight loss result may be likely because it targets both the GLP-1 receptor and the GIP receptor, while semaglutide only targets the GLP-1 receptor.
Tirzepatide vs. Semaglutide: Cost Comparison
Tirzepatide can cost between $1,400 and $1,500 per month without insurance. Due to high demand and ongoing shortages, compounding pharmacies are allowed to create tirzepatide formulations at a more affordable rate—often around half the retail price.
Semaglutide, sold under brand names Wegovy and Ozempic, may cost $1,000–$1,200 monthly without insurance. Compounded semaglutide is a more cost-effective option, usually ranging from $300–$500 per month.
At NP2GO, we offer both compounded tirzepatide and compounded semaglutide to make weight loss treatment more accessible and affordable for our patients. Some insurance providers, such as BCBS Federal, may also cover brand-name GLP-1 medications like Wegovy and Zepbound. If you’re a military personnel, Tricare may give you coverage for Zepbound.
To determine your coverage options, simply call your insurance company. It will probably only require a copay and be cheaper. It is essential to know that plans must opt to cover prescription drugs for weight loss; therefore, it is crucial to check your insurance company’s coverage of this class of drugs and inquire about it during open enrollment.
What Is the Difference Between Semaglutide and Tirzepatide?
Although both tirzepatide and semaglutide are used to assist patients with type 2 diabetes and obesity in losing weight and improving cardiovascular diseases, there are some significant distinctions between them. The main differences between these medicines are that they belong to different classes of drugs and have slightly differing targets in the brain.
Tirzepatide is unique among its class of medications in that it targets both the GIP and GLP-1 receptor agonists. By activating these receptors, tirzepatide functions differently from semaglutide. Semaglutide exclusively targets the GLP-1 receptor agonist. However, it has been on the market longer than tirzepatide and is supported by more extensive research and clinical evidence.
Tirzepatide vs. Semaglutide: What Are the Side Effects?
Both tirzepatide and semaglutide work by slowing digestion and reducing appetite, which can cause similar side effects. The most common include nausea, vomiting, constipation, diarrhea, bloating, and decreased appetite. These symptoms usually improve as your body adjusts to the medication.
Some people may also experience fatigue, burping, or mild stomach discomfort. To minimize side effects, eat smaller meals, stay hydrated, and avoid greasy or high-fat foods.
Tirzepatide may have severe side effects, but these may be rare, which may include:
- Hypoglycemia
- Pancreatitis
- Kidney failure
- Allergic reactions
- Vision changes
- Gastrointestinal issues
- Vision changes
- Stomach pain
Semaglutide’s severe side effects, which are also rare, may include:
- Pancreatitis
- Vision changes
- Kidney failure
- Hypoglycemia
- Gallbladder issues
- Allergic reactions
FAQs About Tirzepatide vs. Semaglutide
Can I combine both semaglutide & tirzepatide?
No, you should not combine semaglutide and tirzepatide. Both medications work similarly to regulate blood sugar and appetite, so using them together increases the risk of side effects such as nausea, vomiting, or dangerously low blood sugar. Always use only one GLP-1 medication at a time, under the guidance of a healthcare professional.
Can I switch from semaglutide to tirzepatide?
Yes, you can switch from semaglutide to tirzepatide under medical supervision. Your provider will guide you on when to stop semaglutide and how to safely start tirzepatide to minimize side effects and ensure proper dosing. Many patients switch when they want stronger weight loss or better blood sugar control.
Do these drugs help with weight loss in patients with type 2 diabetes?
Yes. Both semaglutide and tirzepatide are proven to help people with type 2 diabetes lose weight. They regulate blood sugar, slow digestion, and reduce appetite, leading to gradual and sustained weight loss. Tirzepatide may produce slightly greater results, but both offer significant benefits when combined with diet and exercise.
Which is better to take, semaglutide or tirzepatide?
Both medications are effective for weight loss and blood sugar control, but tirzepatide often produces greater results because it targets two hormones (GIP and GLP-1), while semaglutide targets one (GLP-1). The best choice depends on your health needs, tolerance, and your provider’s recommendation.
How to Access Weight Loss Medications In the US
If you’re ready to begin your weight loss journey, you may be wondering how to access semaglutide and tirzepatide in the U.S. These FDA-approved medications, sold under brand names like Wegovy, Ozempic, Mounjaro, and Zepbound, are available to adults who meet specific eligibility requirements.
You may qualify if:
- You are obese with a BMI of 30 or higher, or
- You are overweight with a BMI of 27 or higher and have a weight-related condition, such as type 2 diabetes, high cholesterol, or hypertension.
At NP2GO, we provide convenient access to compounded semaglutide and tirzepatide for adults ages 18 to 75 who meet these clinical criteria. Our approach goes beyond prescriptions. We focus on helping you achieve sustainable, long-term success.
Our comprehensive weight loss program includes:
- Personalized health coaching with guidance on nutrition, meal planning, and physical activity.
- Telehealth and in-office support, ensuring safe, supervised progress every step of the way.
- Medication that works biologically to reduce hunger and reset how your body regulates weight.
- A supportive community to keep you motivated and accountable throughout your journey.
While new medications continue to emerge for weight loss and type 2 diabetes, semaglutide (Wegovy and Ozempic) and tirzepatide (Mounjaro and Zepbound) remain proven, reliable options for long-term results.
Are You Ready to Achieve Your Weight Loss Goals?
NP2GO offers semaglutide and tirzepatide for weight loss clients in the US, including Oklahoma, Washington, DC., Idaho, Kansas, Michigan, and New Mexico. We start with low-dose injections of semaglutide or tirzepatide to help your body adjust gradually and safely. These medications are clinically proven to reduce appetite, improve metabolism, and promote significant fat loss—many of our patients lose 10–15% of their starting weight.
Here’s how it works.
- Book your consultation: Choose a virtual or in-person visit with one of our licensed providers. You’ll discuss your goals, health history, and ideal weight.
- Start your treatment plan: Our team will guide you through administering your weekly injections at home. Injections ensure proper absorption for the best results.
- Monitor your progress: Join monthly follow-ups to track your success, fine-tune your dosage, and receive ongoing support from our medical team.
With NP2GO, you’ll receive expert care, convenient medication delivery, and continuous guidance, all without frequent clinic visits.
Start your semaglutide or tirzepatide weight loss journey with NP2GO today. We proudly serve clients in Oklahoma and over 28 states nationwide.
Book your consultation now or call 405-696-7003 to take the first step toward a healthier, more confident you.